2026-09-04T20:28:02Z https://mrajournal.in/index.php/files/oai

oai:ojs.mrajournal.in:article/2 2026-07-23T07:32:15Z files:ART

Autonomic Regulation of Cardiovascular Function in Health and Disease Padmini Shukla Autonomic Nervous System (ANS), Cardiovascular Regulation, Homeostasis, Sympathetic Nervous System, Parasympathetic Nervous System, Baroreflex The system that controls the cardiovascular activity is the autonomic nervous system (ANS), which coordinates changes in heart rate, contractile power, and vascular tone moment-to-moment to ensure homeostasis. This hierarchal system uses a balance of sympathetic (fightor-flight) and parasympathetic (rest-and-digest) limbs, which is controlled by brainstem and hypothalamus central command centers. Its mechanism depends on chemical neurotransmission acetylcholine, norepinephrine, as well as fast reflex responses, mostly the baroreflex to maintain hemodynamic equilibrium. This has been shown in health by strong heart rate variability (HRV) and respiratory sinus arrhythmia, which is a measure of autonomic flexibility. Autonomic imbalance on the other hand, which is characterised by sympathetic hyperactivity and parasympathetic withdrawal, is one of the most important pathophysiological processes in heart failure, hypertension, and arrhythmias. The measurement of autonomic activity employs instruments, such as clinical reflexes, to more complex methods of quality such as HRV, baroreflex sensitivity, and microneurography. The therapeutic interventions have developed on the basis of pharmacological principles beta-blockers, RAAS inhibitors to novel device-based neuromodulation which includes vagus nerve stimulation and renal denervation. The future of cardiovascular medicine is in individualized neuromodulation, which builds on the profound knowledge of autonomic physiology to work towards dysregulation with ever greater specificity Sujata Publications 2026-04-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/2 10.62896/mra.1.1.01 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 1, January-June 2026; 1-14 3139-5473 en https://mrajournal.in/index.php/files/article/view/2/1 https://creativecommons.org/licenses/by/4.0

oai:ojs.mrajournal.in:article/3 2026-07-23T07:34:04Z files:ART

Cellular Signaling Networks Governing Metabolic and Stress Responses Swesha Chhabra Cellular signaling, HIF-1α, NRF2, AMPK, mTORC1. The combined effect of metabolic and stress-response signaling networks is necessary to maintain cellular homeostasis. The metabolic networks that are based on insulin, AMPK, and mTOR pathways monitor nutrient and energy conditions to mediate anabolic or catabolic programs. There are stress-response mechanisms, such as the NRF2 antioxidant, HIF-1a hypoxic, and UPR proteolytic pathways, which respond to and counteract a particular insult to the cellular integrity. More importantly, such systems are not compartmentalized but extensively crosstalk, constituting a single adaptive network. Signals are incorporated by key hubs such as the AMPK and mTOR, switching the cell between growth and survival state. Examples of this type of integration include metabolic pathways that have a direct effect on the responses to stress, including glutamine metabolism to support antioxidant defense and lipid peroxidation to support ferroptosis. The network is the basis of significant pathologies when maladaptively regulated: the overload of the network by chronic nutrient excess causes the formation of the metabolic syndrome; the cancer cell intrudes into the normal routes of metabolism and stress adaptation, becoming cancerous; a vicious circle of metabolic failure and neurotoxic stress appears in the neurodegenerative diseases. An approach that should be used to decipher this complexity is systems biology, using omics data and computational modeling to track network interactions and predict behaviors. It was described through this network perspective that therapeutic approaches need to shift away at targeting individual molecules to perturbing key nodes and edges in the network to provide a promising platform to address complicated diseases such as diabetes, cancer, and neurodegeneration. Sujata Publications 2026-04-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/3 10.62896/mra.1.1.02 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 1, January-June 2026; 15-28 3139-5473 en https://mrajournal.in/index.php/files/article/view/3/2 https://creativecommons.org/licenses/by/4.0

oai:ojs.mrajournal.in:article/4 2026-07-23T07:34:59Z files:ART

From Molecular Dysregulation to Systemic Disease: Mechanistic Insights into Pathogenesis Sravani Boyapati Immune Dysregulation, Proteostasis, Neuroinflammation, Inflammaging, Gut-Brain Axis, Autoimmunity The classical perspective of disease as a localized organ failure has been greatly replaced with the paradigm that views illness as a family-wide derailment that can be traced to molecular-scale errors. In this article, the pathogenic continuum of molecular lesion to dysfunction of the organ is traced, leading to the argument of various etiologies focusing on three overlapping primary themes of immune dysregulation, protein homeostasis (proteostasis) loss, and cellular stress. These themes are not independent, but they interact in pathogenic cross-talk, developing selfenhancing loops that spread destruction. We consider underlying pathophysiology, such as Treg / Th17 imbalance, propagation of prion like proteins and immunometabolic reprogramming, which enhance the original insults. This dysregulation intensifies into microenvironmental axes (food gut-brain-immune axis and stromal-immune feedback loops) that propagate and institutionalize tissues pathology. We employ this integrative framework to show paradigmatic systemic diseases, such as rheumatoid arthritis, system sclerosis, multiple system atrophy, and inflammatory bowel disease, in which common mechanisms are observed to have different clinical phenotypes. Lastly, we argue that such a mechanistic knowledge requires a shift onto network-based therapeutics and systems-level diagnostics that will address the higher points of dysregulation and not the terminal points of tissue destruction. Such view conceptualizes pathogenesis as a dynamic, multiscale process and offers the roadmap to creating next-generation, mechanism-informed interventions. Sujata Publications 2026-04-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/4 10.62896/mra.1.1.03 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 1, January-June 2026; 29-42 3139-5473 en https://mrajournal.in/index.php/files/article/view/4/3 https://creativecommons.org/licenses/by/4.0

oai:ojs.mrajournal.in:article/5 2026-07-23T07:36:24Z files:ART

Inflammatory and Oxidative Pathways Driving Multisystem Disease Progression Nidhi Bhatt Suraj Mandal Chronic inflammation, Oxidative stress, Systemic network dysfunction, Reactive oxygen species (ROS), Vicious cycle Modern epidemic of non-communicable chronic diseases requires changes in paradigm of the classical pattern of single-organ pathology to the model of systemic network dysfunction. The key to this change lies in the fact that chronic inflammation and oxidative stress are not secondary events but the primary and linked cause of systemic disease. They create a vicious cycle where inflammatory signaling triggers enzymes such as NADPH oxidase and mitochondrial disruption which releases reactive oxygen species (ROS); which in turn activate major inflammatory pathways such as NF-kB and NLRP3 inflammasome and oxidative damage produces molecules that sustain immune activation. It is a molecular nexus that is a universal pathological mechanism, which destroys the functioning of organ systems. It pushes endothelial dysfunction in atherosclerosis, stimulates insulin resistance in diabetes, promotes neuroinflammation in neurodegenerative diseases, and propagates dysfunction across, such as the gut-liver-brain axis. The systemic production of inflammatory cytokines and oxidized metabolites perpetuates the cycle and the processes like cellular senescence institutionalize it. Thus, chronic diseases can be interpreted as symptoms of some common underlying condition- the existence of dysregulated circuitry in the system. This redefinition requires an abandonment of an organ-focused approach to the treatment of inflammatory-oxidative loop as the root cause of disease and instead governs treatment with the goal of restoring homeostasis to the entire body circuitry. Sujata Publications 2026-04-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/5 10.62896/mra.1.1.04 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 1, January-June 2026; 43-51 3139-5473 en https://mrajournal.in/index.php/files/article/view/5/4 https://creativecommons.org/licenses/by/4.0

oai:ojs.mrajournal.in:article/6 2026-07-23T07:37:28Z files:ART

Genetic, Epigenetic, and Metabolic Determinants of Disease Pathophysiology Subham Mandal Suraj Mandal Integrative Pathophysiology, Genetic Determinism, Genetic Predisposition, Epigenetic Regulation, Metabolic Intermediaries, GenomeEpigenome-Metabolome The classical concept of genetic determinism in pathophysiology is changing to an integrative, systems-based concept. This model acknowledges that disease does not occur due to solitary genetic malformations but as a result of the interplay between genetic susceptibility, epigenetic control, and metabolic mediators and is complex and multidirectional. Genetic variants create a threshold of risk, but their implementation is dynamically considered by epigenome, or a malleable layer of chemical modifications, sensitive to environmental influences such as diet, stress, and toxins. This epigenetic control, in its turn, regulates metabolic pathways, whose metabolites (e.g., acetyl-CoA, SAM) are also fed back to power and control the epigenetic machinery. This leads to self-reinforcing loops that may entrapping cells in pathological states and this is where such phenomena as metabolic memory in diabetes and long-term effects of early-life programming can be explained. This triad has a clinical redefinition of diagnostics and therapeutics. It broadens the biomarker repertoire to encompass epigenetic and metabolic biomarkers and develops interventions-not to a single malfunction but to the reconstruction of the whole system-based on epigenetic drugs and metabolic modulators as well as lifestyle medicine. The model also gives a singular account of comorbidities (e.g., obesity, diabetes and depression) and how conditions such as cancer steal these interactions. Finally, it places pathophysiology as the new product of a disrupted conversation between genome, epigenome, and metabolome, providing new opportunities to prevent and cure it. Sujata Publications 2026-04-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/6 10.62896/mra.1.1.05 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 1, January-June 2026; 52-66 3139-5473 en https://mrajournal.in/index.php/files/article/view/6/5 https://creativecommons.org/licenses/by/4.0

oai:ojs.mrajournal.in:article/9 2026-08-10T08:30:45Z files:ART

Biodiversity and Ethnobotany of Crop Weeds in Sambhajinagar District (Maharashtra): A Review Y.P. Malche Y.A. Ahirrao Crop weeds; Biodiversity; Ethnobotany; Agroecosystem services; Marathwada; Sambhajinagar. Weeds occurring within crop fields are conventionally viewed as competitors that reduce yield, yet a growing body of ecological and ethnobotanical literature indicates that many weed species contribute positively to agroecosystem functioning and rural livelihoods. This review synthesises published evidence on the biodiversity and ethnobotanical significance of crop-field weeds in Sambhajinagar (Aurangabad) district and the wider Marathwada region of Maharashtra, India. It examines regional patterns of weed diversity linked to semi-arid climate, soil type, irrigation regime, tillage and cropping practice; the ecosystem services weeds provide, including pollinator support, soil stabilisation and natural pest regulation; their documented uses as food, fodder, medicine andmaterials for cultural and ritual practice among rural and tribal communities; and the agronomic, ecological and public-health problems posed by invasive and difficult-to-control species such as Parthenium hysterophorus and Cyperus rotundus. Standard ecological methods (quadrat and line-transect sampling, Shannon–Wiener and Simpson diversity indices) and ethnobotanical tools (Use Value, Relative Frequency of Citation, Informant Consensus Factor) used in comparable studies are also reviewed. The synthesis shows that existing floristic and ethnobotanical work on Sambhajinagar district is fragmented, largely single-season, and rarely integrates ecological and ethnobotanical dimensions within one study. The review concludes that an integrated, district-specific investigation combining systematic floristic surveys with structured ethnobotanical documentation is needed to generate an up-to-date baseline for weed biodiversity and associated traditional knowledge, supporting conservation planning and culturally informed, sustainable weed management in the region. Sujata Publications 2026-08-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/9 10.62896/mra.1.2.01 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 2, July-December 2026; 1-8 3139-5473 en https://mrajournal.in/index.php/files/article/view/9/6 Copyright (c) 2026 Author(s) https://creativecommons.org/licenses/by/4.0/

oai:ojs.mrajournal.in:article/10 2026-09-02T11:02:40Z files:ART

Ethnomedicinal Studies of Tridax procumbens L. (Family: Asteraceae) Sonje S.B Shrikanth Maharana Aghade J.B Tridax procumbens, Asteraceae, ethnomedicine, medicinal plants, traditional knowledge, wound healing, phytochemicals, tribal medicine, Odisha. Tridax procumbens L. of Asteraceae family is one of the most common weed found throughout the state of Odisha, India. It is popularly known as coat buttons or Ghamra. This plant has shown an extensive range of traditional ethnomedical uses of plant parts, particularly leaves and aerial portions, in the management of wound, skin disease, bleeding, fever, cough, diarrhea, dysentery, inflammation, liver problems, and hair loss. The plant is known to be used in traditional Ayurvedic system of medicine for management of various diseases as a substitute or complementary to Bhringraj. Phytochemical constituents reported from the plant include flavonoids, alkaloids, tannins, saponins, carotenoids, terpenoids, phytosterols, fatty acids, etc (Gubbiveeranna & Nagaraju, 2016; Ingole et al., 2022). Various pharmacological properties have also been reported from the plant including wound healing, antimicrobial, antioxidant, and antiinflammatory activities among others. Reports by Udupa et al. (1991) have revealed the effect of T. procumbens on wound healing and lysyl oxidase activity, which have been supported by recent studies. The present study focused on the ethnomedical practices of T. procumbens in the state of Odisha as it is a common plant used by the tribal and surrounding villagers of Odisha, particularly Koraput district. However, the traditional uses of the plant do not necessarily imply clinical evidence. More preclinical and clinical trials are needed to ascertain its dose-dependent effect, toxicity, dose, active constituents, and efficacy before it can be recommended for medicinal uses. This review aimed to highlight the botanical description, ethnomedical practices, phytochemistry, pharmacology, and future prospects of T. procumbens. Sujata Publications 2026-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://mrajournal.in/index.php/files/article/view/10 10.62896/mra.1.2.02 Multidisciplinary Research Archives(MRA); MRA: Vol 1, Issue 2, July-December 2026; 9-17 3139-5473 en https://mrajournal.in/index.php/files/article/view/10/7 Copyright (c) 2026 Author(s) https://creativecommons.org/licenses/by/4.0/